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Sleep Health in Lennox-Gastaut Syndrome impacts both Individuals with LGS and their Caregivers

Dixon-Salazar, T.; Leavens, K. J.; Chen, H.; Holick, T. J.; Sweeney, J. A.

2026-09-24 neuroscience
10.64898/2026.09.16.751819 bioRxiv
Show abstract

Sleep disturbances are a significant but underrecognized burden for individuals with Lennox-Gastaut Syndrome (LGS) and their caregivers. We conducted a large LGS caregiver survey to assess sleep quality, duration, specific sleep-related issues, and management strategies. Quantitative analysis revealed a significant association between nocturnal seizures and overall seizure frequency, but general sleep metrics in individuals with LGS (e.g., sleep hours, sleep quality) were not associated with seizure burden. In contrast, caregiver sleep was frequently disrupted - particularly in families who co-slept or reported frequent seizures. Nearly 40% of caregivers experienced nightly sleep disturbances. Respondents reported a range of strategies to manage sleep problems, including medication, environmental adjustments, and behavioral routines. Many also expressed frustrations over the limited effectiveness of strategies and inadequate support for sleep issues. These findings underscore the dual impact of LGS-related sleep disturbances on patients and caregivers, and highlight the need for comprehensive, family-centered approaches to sleep health.

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The top 8 journals account for 50% of the predicted probability mass.

1
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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.