Accuracy Overstates Evidence Grounding and Abstention Reliability in Mammography Vision-Language Models
Qu, B.; Liu, w.; Murrow, M.; Burger, M.; Guo, X.; Vaidya, M. S.; Rose, S. L.; Kantarcioglu, M.; Malin, B. A.; Yin, Z.
Show abstract
Answer accuracy alone cannot determine whether a Vision-Language Model (VLM) relies on clinically relevant mammographic evidence or recognizes when that evidence is unavailable. We introduce an evidence-grounded selective evaluation benchmark that evaluates Pathology classification and Abnormality identification together with label-aware lesion localization. Each original image--task instance is paired with a lesion-removal counterfactual and, when feasible, a size-matched non-lesion random-removal control. Lesion evidence is removed by local tissue reconstruction, while the random-removal view provides a task-irrelevant regional perturbation baseline of comparable spatial extent. We evaluate 16 general-purpose and medically specialized VLMs, including open-source and proprietary models, under a common protocol with the same prompt, image conditions, label spaces, and structured-output requirements. The results show substantial gaps between classification performance and evidence-grounded reliability. InternVL3.5-8B achieved the highest Pathology Macro-F1 at 53.75\%, Huatuo Vision-34B achieved the highest Abnormality Exact Match at 52.44\%, and GPT-5.6 Sol achieved the highest Grounded Answer Success at 21.99\%. Lingshu-7B achieved the highest Counterfactual Specificity at 35.19\%, whereas GPT-5.6 Sol achieved the highest Joint Reliability at 6.47\%. These findings suggest that answer accuracy and abstention behavior can substantially overstate the reliability of current VLMs when predictions are not verified against the visual evidence on which they should depend.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A human-in-the-loop explanation framework for morphologically transparent AI predictions from whole-slide images 94%
- The clinician-AI interface: intended use and explainability in FDA-cleared AI devices for medical image interpretation 91%
- How AI is used in FDA-authorized medical devices: a taxonomy across 1,016 authorizations 90%
Similar papers in this journal
- Model uncertainty estimates for deep learning mammographic density prediction using ordinal and classification approaches 93%
- Breast density prediction from low and standard dose mammograms using deep learning: effect of image resolution and model training approach on prediction quality 93%
- Mammographic density assessed using deep learning in women at high risk of developing breast cancer: the effect of weight change on density 89%
Similar papers in this journal
- Reproducible And Clinically Translatable Deep Neural Networks For Cervical Screening 94%
- PathProfiler: Automated Quality Assessment of Retrospective Histopathology Whole-Slide Image Cohorts by Artificial Intelligence, A Case Study for Prostate Cancer Research 92%
- Automated and Manual Quantification of Tumour Cellularity in Digital Slides for Tumour Burden Assessment 92%
Similar papers in this journal
Similar papers in this journal
- SCU-Net: A deep learning method for segmentation and quantification of breast arterial calcifications on mammograms 95%
- Phase Recognition in Contrast-Enhanced CT Scans based on Deep Learning and Random Sampling 91%
- PSMA-Hornet: fully-automated, multi-target segmentation of healthy organs in PSMA PET/CT images 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.