Quantitative Modelling of Amyloid-β Dynamics in Brain, CSF, and Plasma During Sleep and Wakefulness
Sangeet, S.; Phillips, C. L.; Hoyos, C. M.; D'Rozario, A. L.; Lucey, B. P.; Postnova, S.
Show abstract
Amyloid-beta (A{beta}) accumulation in the brain is linked to Alzheimer's disease. In healthy individuals, A{beta} rises during wakefulness and is cleared during sleep, yet the effects of sleep disturbances on the A{beta} dynamics are unclear. We developed a model, incorporating brain, cerebrospinal fluid (CSF), and plasma, to investigate the A{beta} dynamics along the sleep-wake cycles. The model reproduces the experimentally observed 24-hour A{beta}42 oscillations in CSF (660-760 pg/mL) and plasma (15-19 pg/mL) and predicts brain A{beta} dynamics. Indwelling lumbar catheter data show elevated CSF A{beta}42 levels on the second morning after a full night of sleep compared to first morning. The model predicts this increased level is due to repeated CSF sampling, which affects A{beta} levels through pressure-mediated changes in CSF, impaired sleep associated clearance, or their synergistic effect. These findings provide a framework for understanding A{beta} regulation, highlighting sleep's protective role and the need for non-invasive measurement approaches.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Influence Of Energy Deficiency On The Molecular Processes Of Substantia Nigra Pars Compacta Cell For Understanding Parkinsonian Neurodegeneration: A Comprehensive Biophysical Computational Model 93%
- Physics-informed machine learning for automatic model reduction in chemical reaction networks 92%
- Information encoded in volumes and areas of dendritic spines is nearly maximal across mammalian brains 91%
Similar papers in this journal
- Method to determine whether sleep phenotypes are driven by endogenous circadian rhythmicity or environmental light by combining longitudinal data and personalised mathematical models 93%
- Intraneuronal binding of amyloid beta with reelin -implications for the onset of Alzheimer's disease 92%
- Circadian distribution of epileptiform discharges in epilepsy: candidate mechanisms of variability 92%
Similar papers in this journal
- Basal Ganglia role in learning rewarded actions and executing previously learned choices: healthy and diseased states 90%
- A biophysical minimal model to investigate age-related changes in CA1 pyramidal cell electrical activity 90%
- Observing changes in human functioning during induced sleep deficiency and recovery periods 90%
Similar papers in this journal
Similar papers in this journal
- Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in a Neocortical Microcircuit 90%
- Parsing out the variability of transmission at central synapses using optical quantal analysis 88%
- Five hours total sleep deprivation does not affect CA1 dendritic length or spine density 88%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.