Decarboxylation of indoleacetic acid illuminates its evolution into a plant hormone
Schmidt, V.; Dobrev, P. I.; Knirsch, V.; Muller, K.; Svobodova, B.; Lacek, J.; Marsik, P.; Vosolsobe, S.; Coudert, Y.; Skokan, R.; Petrasek, J.
Show abstract
The evolution of indoleacetic acid (IAA) into the plant hormone auxin remains unclear. Here, we compared IAA response and metabolism in land plants and their closest living relatives, the streptophyte algae, using chemical treatments, phytohormone profiling, and targeted and untargeted metabolomics. Streptophyte algae showed neither plant-like auxin responses nor canonical IAA metabolism. Here, we demonstrate IAA side-chain decarboxylation as a novel pathway of cellular IAA metabolism, operating in streptophyte algae and land plants alike. Decarboxylation also underpinned IAA's innate photolability and yielded cytotoxic intermediates, which also accumulated endogenously under simulated sunlight. Together, these findings establish IAA decarboxylation as a major, conserved metabolic pathway, and suggest that the metabolic constraints arising from IAA's instability and indirect cytotoxicity contributed to its adoption as a plant hormone.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Nicotine biosynthesis completed by cryptic activating glucosylation 94%
- Structure of Photosystem I-FCP from giant kelp uncovers drivers of antenna evolution across the red lineage 94%
- Ancient gene clusters govern the initiation of monoterpenoid indole alkaloid biosynthesis and C3 stereochemistry inversion 94%
Similar papers in this journal
- A cyclo-DOPA 6-O-glucosyltransferase-mediated route for gomphrenin I biosynthesis in Basella alba and Gomphrena globosa 94%
- Parallel evolution of plant alkaloid biosynthesis from bacterial-like decarboxylases 93%
- Conserved spatial patterning of gene expression in independent lineages of C4 plants 93%
Similar papers in this journal
- Sexual life cycle establishes the unicellular red algae Cyanidiophyceae as a genetically tractable model lineage for eukaryotic evolution 94%
- The minimal cell-cycle control system in Marchantia as a framework for understanding plant cell proliferation 93%
- Wounding activates the HSFA1 transcription factors to promote cellular reprogramming in Arabidopsis 93%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.