Genetic background determines allele-specific Pfkelch13-mediated artemisinin tolerance and persistence in Plasmodium falciparum
Ullah, I.; Martin, M. C.; Ndiaye, D.; Volkman, S. K.; Wirth, D. F.
Show abstract
Artemisinin partial resistance (ARTR) in Plasmodium falciparum is mediated by Pfkelch13 mutations but has not emerged in West Africa. Using gene editing, we introduced four Pfkelch13 mutations into a recent Senegalese isolate, evaluating the receptivity of this genetic background to ARTR using the ring-stage survival assay (RSA), a proxy for clinical resistance. One allele conferred the RSA phenotype but was rapidly outcompeted, whereas three conferred stable resistance, revealing allele-specific permissiveness
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Cellular and molecular basis of PfCoronin function in artemisinin resistance in Plasmodium falciparum 95%
- Transmissibility of clinically relevant atovaquone-resistant Plasmodium falciparum by anopheline mosquitoes 93%
- Generation and characterisation of P. falciparum parasites with a G358S mutation in the PfATP4 Na+ pump and clinically relevant levels of resistance to some PfATP4 inhibitors 93%
Similar papers in this journal
- Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea 95%
- Genetic analysis of pyrimidine biosynthetic enzymes in Plasmodium falciparum 94%
- Knockout of Anopheles stephensi immune gene LRIM1 by CRISPR-Cas9 reveals its unexpected role in reproduction and vector competence 93%
Similar papers in this journal
Similar papers in this journal
- Plasmodium falciparum K13 mutations in Africa and Asia present varying degrees of artemisinin resistance and an elevated fitness cost in African parasites 96%
- Genetic surveillance in the Greater Mekong Subregion and South Asia to support malaria control and elimination 93%
- PolyA tracks and poly-lysine repeats are the Achilles heel of Plasmodium falciparum 93%
Similar papers in this journal
- Artemisinin-resistant malaria parasites show enhanced transmission to mosquitoes under drug pressure 93%
- Atypical molecular basis for drug resistance to mitochondrial function inhibitors in Plasmodium falciparum 92%
- Screening the Pathogen Box Compounds for Activity Against Plasmodium falciparum Sporozoite Motility 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.