Absence of a spindle position checkpoint in the fungal pathogen Cryptococcus neoformans
Wang, T. K.; Matthews, J.; Strege, A.; Wallace, E.; Zhou, X.
Show abstract
To maintain genome stability, it is crucial that cells do not initiate cytokinesis until chromosomes have been properly segregated. In the model budding yeast Saccharomyces cerevisiae, a surveillance mechanism called the Spindle Position Checkpoint (SPoC) ensures this coordination by regulating the Mitotic Exit Network (MEN) to couple exit from mitosis and cytokinesis to spindle position. The MEN is conserved in Ascomycota where the orthologous pathway in the fission yeast Schizosaccharomyces pombe, the Septation Initiation Network (SIN), regulates cytokinesis in response to defects in spindle elongation. Here, we show that the MEN/SIN pathway is conserved in the basidiomycetous budding yeast and human pathogen, Cryptococcus neoformans, and controls cytokinesis. However, spindle position or elongation does not regulate pathway activation or cell cycle progression in C. neoformans. In essence, there appears to be no SPoC in this organism to delay cytokinesis upon defects in mitosis. We speculate that while increasing the risk of genome instability, the lack of a SPoC might facilitate C. neoformans's ability to change ploidy in the host.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Molecular features of Myosin F adapted for driving actin flows in Toxoplasma gondii 92%
- The interaction between the tumour suppressor Dlg1 and the MAGUK protein CASK is required for oriented cell division in mammalian epithelia 91%
- Negative feedback between the APC/C and Cep152 at the centrosome regulates mitotic spindle assembly 91%
Similar papers in this journal
Similar papers in this journal
- Cellular dynamics and genomic identity of centromeres in Rice Blast 92%
- Molecular insights into the dual activation of PomZ, a ParA/MinD P-loop ATPase, by the two ATPase activating proteins PomX and PomY 92%
- Genetic and genomic analyses reveal boundaries between species closely related to Cryptococcus pathogens 92%
Similar papers in this journal
- Homeodomain protein Sxi1α regulates cell-cell fusion during distinct sexual reproduction modes in Cryptococcus deneoformans 94%
- A RID-like cytosine methyltransferase homologue controls sexual development in the fungus Podospora anserina 93%
- Loss of meiotic double strand breaks triggers recruitment of recombination-independent pro-crossover factors in C. elegans spermatogenesis 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.