Epithelial and γδ T cell CD47 have complementary yet distinct roles in regulating γδ intraepithelial lymphocyte migration
Parthasarathy, A.; Fischer, M. A.; Parkos, C. A.; Edelblum, K. L.
Show abstract
Intraepithelial lymphocytes expressing the {gamma}{delta} T cell receptor ({gamma}{delta} IEL) continuously survey the intestinal epithelium to promote mucosal host defense. Although {gamma}{delta} IELs migrate in and out of the lateral intercellular space (LIS) between adjacent enterocytes, the molecular mechanisms governing their migratory behavior are incompletely understood. Based on the known role of CD47, or integrin associated protein (IAP), in mediating neutrophil transepithelial migration, we investigated whether CD47 expression reflects a conserved mechanism regulating {gamma}{delta} IEL surveillance behavior. Here, we report that conditional CD47 deletion on intestinal epithelial cells or {gamma}{delta} T cells had no effect on IEL composition. Using intravital imaging, we identified complementary roles for CD47 on {gamma}{delta} IELs and epithelial cells, with epithelial CD47 restricting {gamma}{delta} IEL motility and {gamma}{delta} T-cell-derived CD47 promoting cell migration. Further investigation revealed that both CD47 and CD18 contribute to {gamma}{delta} IEL surveillance behavior, although CD47 regulates {gamma}{delta} IEL migration in a CD18-independent manner.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Osteopontin and iCD8α cells promote intestinal intraepithelial lymphocytes homeostasis 92%
- IL-33 promotes transcriptional and metabolic adaptations of tissue-resident Th2 cells 92%
- The IL-12 and IL-23-Dependent NK Cell Response is Essential For Protective Immunity Against Secondary Toxoplasma gondii Infection. 91%
Similar papers in this journal
- Macrophages regulate gastrointestinal motility through complement component 1q 92%
- Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation 92%
- Endothelial SIRPα signaling controls thymic progenitor homing for T cell regeneration and antitumor immunity 92%
Similar papers in this journal
- Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling 92%
- IL-10 inhibits STAT1-dependent macrophage accumulation during microbiota-induced colitis 92%
- Liver X Receptor regulates Th17 and RORγt+ Treg cells by distinct mechanisms 92%
Similar papers in this journal
- Myo1f has an essential role in γδT intraepithelial lymphocyte adhesion and migration 93%
- Multiple environmental signaling pathways control the differentiation of RORγt-expressing regulatory T cells 92%
- Studying the cellular basis of small bowel enteropathy using high-parameter flow cytometry in mouse models of primary antibody deficiency 92%
Similar papers in this journal
- Lysophosphatidic acid-mediated GPR35 signaling in CX3CR1+ macrophages regulates the intestinal cytokine milieu 92%
- Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes 92%
- Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.