A Cajal body assembly factor regulates cell fate transitions in Arabidopsis
Faturova, J.; Raxwal, V. K.; Dubois, M.; Cairo, A.; Crhak Khaitova, L.; Bukovcakova Valuchova, S.; Drs, M.; Mikulkova, P.; Vargova, A.; Malinska, K.; De Veylder, L.; Riha, K.
Show abstract
Ribonucleoprotein (RNP) condensates are emerging as key regulators of cell fate transitions, yet their functions have been largely linked to mRNA storage and translational control. Here, we uncover a role for Cajal body (CB)-mediated pre-mRNA splicing in coordinating the transition from stem cell divisions to differentiation in plants. We identify THREE-DIVISION MUTANT 3 (TDM3) as a cell cycle-regulated factor required for post-mitotic CB assembly. Loss of TDM3 or the CB scaffold protein COILIN delays differentiation and prolongs formative cell divisions. Transcriptome analysis revealed that TDM3 and COILIN jointly regulate pre-mRNA splicing, including transcripts controlling cell cycle and fate transitions. These findings establish CB-mediated splicing as a mechanism linking cell cycle progression to cellular differentiation.
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