β-Adrenergic inhibition of exocytotic surface deposition of MHCII molecules in reactive astrocytes is mediated by amisyn
Vrsnik, J.; Bozic, M.; Bunc, Z.; Potokar, M.; Sugiyama, K.; Dolinar, K.; Pirkmajer, S.; Anderluh, G.; Kreft, M.; Milosevic, I.; Jorgacevski, J.; Zorec, R.; Stenovec, M.
Show abstract
Degeneration of the locus coeruleus, a noradrenergic nucleus, reduces noradrenaline bioavailability in the central nervous system and promotes neuroinflammation via reactive astrocytes, although the underlying mechanisms remain unclear. We investigated whether interferon-{gamma}-induced expression of major histocompatibility complex class II (MHCII), a marker of pro-inflammatory reactive astrocytes, is regulated by adrenergic receptors and amisyn. {beta}-Adrenergic, but not -adrenergic, stimulation increased cyclic adenosine monophosphate (cAMP) and reduced MHCII expression, as detected immunocytochemically, in human and rat astrocytes. {beta}-Adrenergic treatment altered transient exocytosis of lysosome-like vesicles, increasing event frequency and reducing fusion-pore conductance and dwell time, thereby limiting MHCII surface expression. Overexpression of wild-type amisyn inhibited surface expression of MHCII and the lysosomal marker CD63 and reduced fusion-pore conductance and dwell time. Conversely, amisyn knockdown enhanced full fusion exocytosis of larger vesicles and abolished {beta}-adrenergic effects, indicating that amisyn mediates {beta}-adrenergic inhibition of exocytosis and MHCII surface deposition.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Norepinephrine activates β1-adrenergic receptors localized to the inner nuclear membrane in cortical astrocytes 93%
- Neurotensin receptor 2 is induced in astrocytes and brain endothelial cells in relation to status epilepticus and neuroinflammation following pilocarpine administration in rats 92%
- Deletion of calcineurin from GFAP-expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na+/K+ ATPase. 92%
Similar papers in this journal
Similar papers in this journal
- BDNF/TrkB.T1 signaling is a novel mechanism for astrocyte morphological maturation 93%
- Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66-independent targeting of NogoA 92%
- Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor 92%
Similar papers in this journal
- Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABAA receptors 91%
- Reduction in CD11c+ microglia correlates with clinical progression in chronic experimental autoimmune demyelination 91%
- Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of Phosphodiesterase 2A 91%
Similar papers in this journal
- RGS10 Attenuates Systemic Immune Dysregulation Induced by Chronic Inflammatory Stress 91%
- Inhibition of microglial GBA hampers the microglia-mediated anti-oxidant and protective response in neurons 91%
- Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.