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Dyslexia is characterized by atypical predictive coding specific to the left subcortical auditory pathway

Jaervikylae, H.; Tabas, A.; von Kriegstein, K.

2026-08-20 neuroscience
10.64898/2026.08.17.745222 bioRxiv
Show abstract

Developmental dyslexia is a specific, highly prevalent and often debilitating reading and spelling disorder with unknown neurocomputational mechanisms. Here we discovered, in a preregistered functional magnetic resonance imaging study optimized for the subcortical sensory pathway, that dyslexia is characterized by altered predictive coding in left-hemispheric auditory sensory pathway nuclei. The neurocomputational alterations were related to one of the two main dyslexia risk scores, indicating a crucial role for dyslexia pathophysiology.

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