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Blastema cells exhibit intrinsic migratory capacity but fail to induce osteoblast off-bone migration during Zebrafish fin regeneration

Sehring, I. M.; Weidinger, G.

2026-08-07 developmental biology
10.64898/2026.08.06.743241 bioRxiv
Show abstract

Zebrafish bone regeneration is a highly efficient process, enabling the complete restoration of an amputated fin within few weeks. The hallmark of this epimorphic regeneration is the formation of a blastema atop of a bony fin ray. Osteoblasts near the injury site dedifferentiate and migrate off the bone to contribute to the developing blastema. We show that an injury or a blastema alone is not sufficient to trigger off-bone migration of osteoblasts. Surprisingly, we found that blastema cells themselves possess intrinsic migratory properties. Moreover, when multiple injury sites are present, a preferential distal migration could be observed. We conclude that multiple injuries are hierarchical organized, and that injuries with the highest regenerative potential take priority.

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