Bone Lymphatic Endothelial Cells Form a Distinct Skeletal Population and Drive Skeletal Repair
Jain, S.; Li, J.; Zhang, J.; Cai, H.; Wu, Y.; Yang, Y.; Ye, M.; Risbud, M.; Chen, J.; Kusumbe, A.
Show abstract
Bone regeneration relies on specialized vascular niches, yet the contribution of lymphatic vessels across distinct skeletal sites remains poorly understood. Here, we identify bone lymphatics as an essential component of the regenerative microenvironment in the mandible and long bones. We demonstrate that bone lymphatic endothelial cells (LECs) constitute a specialized endothelial population that is transcriptionally and spatially distinct from periosteal LECs. During skeletal repair, bone LECs reactivate a regenerative transcriptional programme, and promote mandibular and fracture healing. In osteonecrosis of the jaw and periodontitis, bone lymphatic-associated signalling is disrupted, identifying impaired lymphatic function as a shared feature of mandibular disease. Therapeutic activation of VEGFC-FLT4 signalling during injury or mandibular disease restores lymphangiogenesis, enhances osteogenesis, and markedly improves bone regeneration. Together, our findings advance the paradigm-shifting role of bone lymphatics positive regulators of bone regeneration and identify lymphatic activation as a promising therapeutic strategy to enhance bone regeneration in mandibular diseases.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Cellular and molecular landscapes of human tendons across the lifespan revealed by spatial and single-cell transcriptomics 94%
- Conduit integrity is compromised during acute lymph node expansion 92%
- Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging and inflammation 91%
Similar papers in this journal
- The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence 94%
- O-GlcNAc glycosylation orchestrates fate decision and niche function of bone marrow stromal progenitors 93%
- Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone 93%
Similar papers in this journal
- Bone marrow adipogenic lineage precursors (MALPs) promote osteoclastogenesis in bone remodeling and pathologic bone loss 93%
- Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation 93%
- Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.