Inferring the relative contributions of evolutionary processes shaping X chromosome dynamics in the common marmoset (Callithrix jacchus) in the presence of twinning and hematopoietic chimerism
Soni, V.; Versoza, C. J.; Shah, D.; Pfeifer, S. P.; Jensen, J. D.
Show abstract
The common marmoset (Callithrix jacchus) is a biomedically important species that is characterized by two unusual biological traits -- a high frequency of twin births and hematopoietic chimerism -- that preclude the application of many commonly used population genomic approaches for quantifying evolutionary processes. In this study, we directly account for both factors in order to estimate fine-scale mutation and recombination rate maps, as well as to infer the demographic and selective processes shaping variation, on the common marmoset X chromosome. Comparing our findings to estimates recently inferred on the autosomes of this species, we find reduced rates of mutation and recombination on the X, as expected. Furthermore, population sex ratios are inferred to be nearly equal, and the appropriately rescaled autosomal population history fits the X chromosome well. Finally, we report evidence of recent selective sweeps targeting a number of X-linked genes, including several of significant biomedical relevance. Overall, these analyses provide novel insights into the evolutionary processes shaping X chromosome evolution in this biomedically-relevant primate model.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Flexible mixture model approaches that accommodate footprint size variability for robust detection of balancing selection 94%
- A likelihood approach for uncovering selective sweep signatures from haplotype data 94%
- Accounting for chimerism in demographic inference: reconstructing the history of common marmosets (Callithrix jacchus) from high-quality, whole-genome, population-level data 93%
Similar papers in this journal
Similar papers in this journal
- Empirical validation of the nearly neutral theory at divergence and population genomic scale using 150 mammals genomes 96%
- Inferring domestic goat demographic history through ancient genome imputation 94%
- Genomes from 117 vertebrate species reveal rapidly evolving segmental duplication landscapes 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.