Dissociable thalamic oscillatory mechanisms support motor sequence learning
Voegtle, A.; Buentjen, L.; Repplinger, S.; Nasuto, S. J.; Andrade, A. d. O.; Deliano, M.; Knight, R. T.; Ivry, R. B.; Sweeney-Reed, C. M.
Show abstract
The ventrointermediate nucleus of the thalamus (VIM) is implicated in motor sequence learning, yet the underlying neural mechanisms remain unclear. We recorded intracranial activity from the human VIM during a serial reaction time task to determine how neural dynamics support learning. Participants responded faster during repeating than randomized sequences. Beta-to-low-gamma activity was greater during repeating sequences and elevated relative to the prestimulus baseline, consistent with emergence and stabilization of learned motor representations. In contrast, beta-phase modulation of high-frequency activity decreased progressively from rest to random to repeated sequence execution. Stronger phase-amplitude coupling was associated with faster responses, reaching significance in the random condition. These findings reveal a dissociation between power and cross-frequency coupling. Together they suggest that thalamic dynamics contribute to motor learning through multiple mechanisms: beta-band power reflects the emergence of learned motor representations, whereas beta-high-frequency coupling is enhanced when the context is less predictable.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Lateral Prefrontal Theta Oscillations Causally Drive a Computational Mechanism Underlying Conflict Expectation and Adaptation 95%
- Spatiotemporal brain hierarchies of auditory memory recognition and predictive coding 95%
- Timing along the cardiac cycle modulates neural signals of reward-based learning 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.