The Proposed Bone Post-Arterial Type R Capillaries Resolve into Venous and Fatty Acid-Handling Endothelial Cells
Jain, S.; Joseph, J. D.; Liu, H.; Bhowmick, N. R.; Yang, Y.; Mundapat, S. N.; Machan, R.; Glaviano, A.; Chandra, A.; Dalan, R.; Chen, J.; Verma, N. K.; Cohen-Solal, M.; Risbud, M. V.; Bozec, A.; Kusumbe, A. P.
Show abstract
Endothelial specialization is increasingly recognized as a fundamental regulator of tissue homeostasis, yet the cellular diversity of the skeletal vasculature remains incompletely resolved. Here, we integrate large-scale single-cell transcriptomics, cross-tissue comparisons, and imaging to comprehensively define endothelial heterogeneity across the skeleton. Our analyses demonstrate that the proposed post- arterial "type R" endothelial population is not a distinct endothelial subtype but instead comprises canonical venous endothelial cells and fatty acid-handling endothelial state. RNA velocity supports a venous continuum, while the proposed type R markers FMO2, and AQP7 lack both endothelial and skeletal specificity. The fatty acid-handling endothelial state, characterized by Lpl and Cd36 is conserved across multiple skeletal sites and non-skeletal tissues, indicating a general endothelial metabolic programme. Within bone, this endothelial state expands following high-fat diet and is suppressed during injury. Together, these findings redefine skeletal endothelial heterogeneity and establish the proposed type R population as part of a venous continuum.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Single cell transcriptomics reveals chondrocyte differentiation dynamics in vivo and in vitro 94%
- The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth 93%
- Sex biased human thymic architecture guides T cell development through spatially defined niches 92%
Similar papers in this journal
Similar papers in this journal
- The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence 94%
- Single nuclei transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration 94%
- Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche 94%
Similar papers in this journal
- Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis 94%
- Transcriptional profile of the rat cardiovascular system at single cell resolution 93%
- Cellular and molecular landscapes of human tendons across the lifespan revealed by spatial and single-cell transcriptomics 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.