Beige/brown fat-mediated cardiac protection from high-fat diet is dependent on adipocyte beta3-adrenergic receptor
Cascarano, L.; Michel, L.; Esfahani, H.; De Mulder, D.; Melecchi, A.; Bouzin, C.; Loriot, A.; Ambroise, J.; Pezzica, S.; Carli, F.; Sabatini, S.; Gatto, L.; Dessy, C.; Gastaldelli, A.; Balligand, J.-L.
Show abstract
Cardiometabolic diseases associated with obesity are continuously increasing worldwide. Yet, current therapeutic strategies remain insufficient to improve patient outcomes. The beta3-adrenergic receptor ({beta}3AR) promotes lipolysis in adipose tissue (AT) and thermogenesis specifically in brown adipose tissue (BAT). In mice, BAT activation also improves systemic metabolism and limits cardiometabolic damage. While BAT is limited in humans (e.g., with ageing and obesity), {beta}3AR activation induces beige adipocytes within white adipose depots with similar thermogenic properties. To study the role of adipocyte {beta}3AR in the regulation of cardiac metabolism and remodeling, mice with/without adipocyte-specific {beta}3AR genetic deletion were fed a high-fat-sucrose (HF-S) diet and treated with the selective {beta}3AR agonist CL316,243 (CL). The metabolic and cardiac protection following {beta}3AR activation was abrogated upon {beta}3AR deletion in adipocytes, together with the beiging of the epididymal (visceral) AT, highlighting a critical role of adipose {beta}3AR signalling in mediating these benefits. Multi-omic analysis of AT and cardiac samples identified CL-induced secreted mediators of the crosstalk between AT and the heart. Therefore, adipocyte {beta}3AR is critical for the adipose-cardiac communication and supports the therapeutic potential of targeting {beta}3AR for the management of obesity-related cardiometabolic diseases.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- dATP Elevation Induces Myocardial Metabolic Remodeling to Support Improved Cardiac Function 95%
- mTORC1 Regulates the Metabolic Switch of Postnatal Cardiomyocytes During Regeneration 94%
- In vitro and in vivo roles of glucocorticoid and vitamin D receptors in the control of cardiomyocyte proliferative potential 94%
Similar papers in this journal
- Extracellular Matrix Abnormalities Contribute to Cardiac Insulin Resistance and Associated Dysfunction in Diet-induced Obese Mice 97%
- Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue. 95%
- Adiponectin-receptor agonism prevents right ventricular tissue pathology in a mouse model of Duchenne muscular dystrophy 95%
Similar papers in this journal
- A Remarkable Adaptive Paradigm Of Heart Performance And Protection Emerges In Response To The Constitutive Challenge Of Marked Cardiac-Specific Overexpression Of Adenylyl Cyclase Type 8 95%
- SIRT2 inhibition protects against cardiac hypertrophy and heart failure 95%
- Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils 95%
Similar papers in this journal
- Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High Fat, High Fructose, High Cholesterol Diet Mouse Model 95%
- Dysfunctional Mitochondria in Cardiac Fibers of a Williams-Beuren Syndrome Mouse Model 94%
- Hyperuricaemia Does Not Interfere With Aortopathy In A Murine Model Of Marfan Syndrome 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.