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Patterns of Gabapentin Use in Patients With Cervical Spondylotic Myelopathy

Warner, B. C.; Arkam, F.; Yakdan, S.; Hammo, A.; Ray, W. Z.; Wilcox, A.; Foraker, R.; Lu, C.; Greenberg, J. K.

2026-07-28 neurology
10.64898/2026.07.27.26358977 medRxiv
Show abstract

Cervical spondylotic myelopathy (CSM) is the most common cause of nontraumatic spinal cord dysfunction in adults and is an increasingly important source of disability as populations age. Gabapentin is widely prescribed for neuropathic pain and may therefore be used for symptoms related to known or undiagnosed CSM. However, there is sparse evidence related specifically to gabapentin's use for CSM-related pain. We investigate gabapentin use and trends over time in patients with CSM compared to matched controls. We observed that gabapentin prescriptions were higher in CSM patients compared to controls across two multi-hospital datasets. These results highlight the need for further research into pharmacologic treatment for chronic pain in CSM.

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