Insulin controls olfactory gain at the first central synapse by regulating periglomerular neuron excitability
Oncul, M.; Stefens, C.; Smith, E. L.; Choudhuri, S.; Filippi, B. M.; Johnston, J.
Show abstract
Sensory processing is dynamically tuned by internal state, yet how metabolic signals reshape the earliest stages of sensory circuits remains poorly understood. Here we identify a circuit mechanism by which satiety suppresses olfactory sensitivity at the first central synapse in the mouse olfactory bulb. Using a within-animal paradigm modelling fasted and glucose-induced sated states, we show that satiety impairs food-finding behaviour and reduces olfactory receptor neuron input to the olfactory bulb. Periglomerular (PG) cells, which co-express insulin receptors and the potassium channel Kv1.3, mediate this effect: insulin inhibits the low-voltage-activated Kv1.3 current in PG cells, increasing their spontaneous and odour-evoked activity. This heightened PG cell activity drives enhanced presynaptic inhibition of olfactory receptor neuron terminals, dampening sensory input before it reaches mitral cells. These findings establish insulin-dependent presynaptic inhibition of PG cells as a key locus of state-dependent sensory gain control.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Feedforward and feedback mechanisms cooperatively regulate rapid experience-dependent response adaptation in a single thermosensory neuron type 95%
- A silent Kv channel subunit shapes PV neuron action potential waveform and short-term synaptic plasticity during high-frequency firing 95%
- A neural circuit for competing approach andavoidance underlying prey capture 95%
Similar papers in this journal
Similar papers in this journal
- Immature olfactory sensory neurons provide behaviourally relevant sensory input to the olfactory bulb 95%
- Antagonistic odor interactions in olfactory sensory neurons are widespread in freely breathing mice 95%
- Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types 95%
Similar papers in this journal
- Multisensory integration of social signals by a pathway from the basal amygdala to the auditory cortex in maternal mice 96%
- Subanesthetic ketamine reactivates adult cortical plasticity to restore vision from amblyopia 95%
- A brainstem to hypothalamic arcuate nucleus GABAergic circuit drives feeding 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.