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Water stress adaptive responses in plants require movement of ABA and AB-aldehyde from vascular to target tissues

Anfang, M.; Kiradjiev, K. B.; Ben Yaakov, S.; Gothilf, D.; Kanstrup, C.; Bitman, B.; Jepson, J. M.; Fellus-Alyagor, L.; Hirsch, D.; Galperin, V. E.; Watanabe, S.; Okamoto, M.; Kumar, R.; Crocoll, C.; Morghen, S.; Hamann, T.; Brotman, Y.; Seo, M.; Nour-Eldin, H. H.; Sturrock, C. J.; Mehra, P.; Bennett, M. J.; Rowe, J. H.; Band, L. R.; Shani, E.

2026-07-23 plant biology
10.64898/2026.07.22.739638 bioRxiv
Show abstract

Vascular plants rapidly coordinate root and shoot responses to water stress. Abscisic acid (ABA) mediates these adaptations; however, it remains unclear which cells produce ABA, whether ABA synthesis shifts during stress, and whether ABA movement is required for its adaptive functions. Here, we map ABA biosynthesis at cellular resolution in Arabidopsis and report that water-stress adaptive responses in roots and shoots require movement of ABA and its precursor AB-aldehyde from vascular tissues to target cells. We suggest that ABA accumulation arises from two parallel routes: (i) ABA synthesized in the vasculature via ABA2 and AAO3, then moving to guard cells, and (ii) phloem-derived AB-aldehyde being converted to ABA in the epidermis or bundle sheath by AAO1 and AAO2. Finally, we predict that tightly packed cells beneath leaf veins facilitate efficient ABA delivery to guard cells, an anatomical arrangement that has enabled angiosperms to evolve the use of ABA to rapidly close stomata.

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