Community diversity favors coexistence between bacteria and parasitic bacteriophages
Blazanin, M.; An, W.; Tolkoff, A. B.; Turner, P. E.
Show abstract
Microbial communities often contain diverse bacteria and their specific viruses (bacteriophages). Lytic phages frequently select for host bacteria to evolve resistance, in-turn threatening phage extinction. However, in nature phage-bacteria interactions do not occur in isolation, but within complex communities containing other species. To test how community context can alter resistance evolution and phage persistence, we experimentally evolved Pseudomonas aeruginosa bacteria and a Pseudomonas-targeting phage with and without a community representing a cystic fibrosis disease pulmonary infection. Phages selected for rapid evolution of receptor-mediated resistance, regardless of community context. However, susceptible bacteria often persisted due to resistance-growth trade-offs. A diverse community favored increased frequencies of susceptibility, fueling higher phage densities and fewer phage extinctions. Our findings show that community complexity can constrain the evolution of phage resistance in bacteria, promoting host-parasite coexistence and fostering microbial diversity.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Antimicrobial resistance level and conjugation permissiveness shape plasmid distribution in clinical enterobacteria 96%
- The evolution of robustness and fragility during long-term bacterial adaptation 96%
- One gene, multiple ecological strategies: a biofilm regulator is a capacitor for sustainable diversity 96%
Similar papers in this journal
- Patterns of gene content and co-occurrence constrain the evolutionary path toward animal association in CPR bacteria 95%
- Fatty acid synthesis knockdown promotes biofilm wrinkling and inhibits sporulation in Bacillus subtilis 95%
- Phage-plasmids spread antibiotic resistance genes through infection and lysogenic conversion 95%
Similar papers in this journal
- Interactions between strains govern the eco-evolutionary dynamics of microbial communities 97%
- Competition between phage-resistance mechanisms determines the outcome of bacterial co-existence 96%
- Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections 96%
Similar papers in this journal
- Host immunity alters successional ecology and stability of the microbiome in a C. elegans model 96%
- Phenotypic and genomic diversification in complex carbohydrate degrading human gut bacteria 95%
- Species-scale genomic analysis of S. aureus genes influencing phage host range and their relationships to virulence and antibiotic resistance genes 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.