Back

Genipin Alleviates Sleep Deficiencies Caused by α-Synuclein Toxicity in a Drosophila melanogaster Model of Parkinsons Disease

Davis, O. M.; Sappenfield, A. H.; Fairman, R.

2026-07-21 neuroscience
10.64898/2026.07.16.738995 bioRxiv
Show abstract

Parkinsons disease is predominantly characterized by dopaminergic neurodegeneration linked to toxic aggregation of -synuclein. Genipin, a bioactive iridoid, was previously shown to improve the motility and survival deficits caused by pan-neuronal expression of native -synuclein in a transgenic Drosophila melanogaster model system. We show that expression of -synuclein causes sleep deficits and that genipin treatment rescued these sleep deficits, increasing total sleep and consolidating nighttime sleep relative to untreated -synuclein-expressing fruit flies. Our findings extend genipins protective profile in Drosophila melanogaster and highlight sleep regulation as an additional phenotype responsive to -synuclein-targeted interventions.

Matching journals

The top 10 journals account for 50% of the predicted probability mass.

1
Sleep
◐ 58 papers in training set
Top 0.1%
13.2%
Similar papers in this journal
2
Frontiers in Neuroscience
○ 256 papers in training set
Top 0.1%
8.0%
Similar papers in this journal
3
Scientific Reports
○ 3612 papers in training set
Top 11%
6.4%
Similar papers in this journal
4
npj Parkinson's Disease
○ 105 papers in training set
Top 0.4%
5.6%
Similar papers in this journal
5
eneuro
● 439 papers in training set
Top 2%
4.1%
Similar papers in this journal
6
Frontiers in Behavioral Neuroscience
○ 49 papers in training set
Top 0.2%
3.3%
7
Journal of Neurogenetics
○ 11 papers in training set
Top 0.1%
2.8%
8
eLife
● 5828 papers in training set
Top 39%
2.7%
9
The Journal of Neuroscience
● 1025 papers in training set
Top 6%
2.4%
10
PLOS ONE
● 5266 papers in training set
Top 40%
2.4%
50% of probability mass above
11
Journal of Sleep Research
○ 36 papers in training set
Top 0.3%
2.4%
12
Movement Disorders
○ 71 papers in training set
Top 0.4%
2.2%
13
Sleep Advances
◐ 11 papers in training set
Top 0.1%
1.9%
14
Journal of Biological Rhythms
○ 25 papers in training set
Top 0.1%
1.8%
15
Neurobiology of Disease
○ 148 papers in training set
Top 2%
1.7%
16
Disease Models & Mechanisms
139 papers in training set
Top 1%
1.6%
17
Frontiers in Cellular Neuroscience
○ 91 papers in training set
Top 1%
1.5%
18
Molecular and Cellular Neuroscience
○ 20 papers in training set
Top 0.2%
1.5%
19
Frontiers in Aging Neuroscience
○ 74 papers in training set
Top 1%
1.2%
20
Neuroscience
○ 97 papers in training set
Top 1%
1.2%
21
Frontiers in Synaptic Neuroscience
○ 17 papers in training set
Top 0.1%
1.2%
22
Biology Open
● 156 papers in training set
Top 3%
1.1%
23
iScience
○ 1154 papers in training set
Top 30%
1.1%
24
Sleep Medicine
○ 19 papers in training set
Top 0.3%
1.1%
25
European Journal of Neuroscience
○ 189 papers in training set
Top 3%
0.9%
26
Parkinsonism & Related Disorders
○ 25 papers in training set
Top 0.4%
0.9%
27
International Journal of Molecular Sciences
○ 494 papers in training set
Top 14%
0.9%
28
G3 Genes|Genomes|Genetics
◐ 351 papers in training set
Top 4%
0.9%
29
Cells
○ 249 papers in training set
Top 7%
0.9%
30
NeuroToxicology
○ 14 papers in training set
Top 0.3%
0.9%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.