Development of a Core Outcome Set for Mild Cognitive Impairment (MCI-COS): Recommendations from a multistakeholder Delphi consensus study
Gabb, V. G.; Harding, S.; McNair, A.; Clayton, J.; Barrett-Muir, W.; Richardson, A.; Dooley, J.; Webb, J.; Lemke, T.; Coulthard, E.; Turner, N.
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INTRODUCTION: Meaningful research into mild cognitive impairment (MCI) is limited by trial outcomes which are heterogeneous and may not always be important to patients. We developed a core outcome set (COS) for the evaluation of interventions in patients with MCI (MCI-COS). METHODS: A scoping umbrella review and interviews with stakeholders (patients, family members, and professionals) determined a longlist of potential outcomes. A modified two-round Delphi study and consensus meeting agreed the final MCI-COS. RESULTS: A ten-item COS was identified: cognitive functioning (non-memory), memory, mental health and wellbeing, social functioning/relationships, quality of life, everyday functioning and independence, biomarkers of brain health, progression to dementia, general/physical health, and sleep. DISCUSSION: Embedding the COS into clinical trials and practice will reduce outcome heterogeneity and encourage transparent reporting of outcomes prioritised by stakeholders, beyond those typically included in trials for MCI.
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