A polarity-controlled Tad nanomachine enables prey invasion in a bacterial predator
Tesseur, C.; Denise, R.; Santin, Y. G.; Laloux, G.
Show abstract
Type IV pili are dynamic surface appendages assembled by envelope-spanning nanomachines that mediate diverse bacterial interactions, yet how these systems are adapted to predatory lifestyles remains poorly understood. Here we investigate the tight adherence (Tad) machinery of the obligate predator Bdellovibrio bacteriovorus. Using inducible CRISPR interference combined with live-cell and microfluidics imaging, we show that the Tad system is essential for prolonged prey attachment and subsequent prey remodeling and invasion. The machinery assembles specifically at the invasive cell pole before prey encounter and is temporally coordinated with the predatory cell cycle. We further demonstrate that polar localization of the Tad machinery depends on the polarity hub RomR. In addition, the atypical TadZA fusion ATPase interacts with RomR, identifying a potential molecular link between polarity control and Tad assembly. Together, our findings reveal how spatiotemporal control of a conserved filament system supports bacterial predation.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Transient inhibition of cell division in competent pneumococcal cells results from deceleration of the septal peptidoglycan complex 97%
- A deterministic, c-di-GMP-dependent genetic program ensures the generation of phenotypically similar, symmetric daughter cells during cytokinesis 97%
- McaA and McaB control the dynamic positioning of a bacterial magnetic organelle 96%
Similar papers in this journal
- Spatio-temporal control of DNA replication by the pneumococcal cell cycle regulator CcrZ 97%
- Diverse phage defence systems define West African South American pandemic Vibrio cholerae 96%
- Gamma-Mobile-Trio systems define a new class of mobile elements rich in bacterial defensive and offensive tools 96%
Similar papers in this journal
- The RecA-directed recombination pathway of natural transformation initiates at chromosomal replication forks in Streptococcus pneumoniae. 97%
- Oxygen depletion and nitric oxide stimulate type IV MSHA pilus retraction in Vibrio cholerae via activation of the phosphodiesterase CdpA 96%
- Specificities of Chemosensory Receptors in the Human Gut Microbiota 96%
Similar papers in this journal
- Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq 96%
- Bacterial vampirism mediated through taxis to serum 96%
- Non-cognate immunity proteins provide broader defenses against interbacterial effectors in microbial communities 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.