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Partial breast irradiation after lumpectomy with omission of surgical axillary evaluation

Roth O'Brien, D. A.; Boe, L. A.; Mueller, B. A.; Montagna, G.; Hahesy, E. N.; Cuaron, J. J.; Choi, J. I.; Bernstein, M. B.; McCormick, B.; Powell, S. N.; Khan, A. J.; Braunstein, L. Z.

2026-07-01 oncology
10.64898/2026.06.29.26356836 medRxiv
Show abstract

Sentinel lymph node biopsy (SLNB) is increasingly omitted in early-stage breast cancer, often prompting whole-breast irradiation (WBI). We evaluated partial-breast irradiation (PBI) without axillary surgery among 78 clinically node-negative patients (median age 75) treated from 2014 to 2022. After 53-month median follow-up, no ipsilateral, regional, or distant recurrences occurred. These results demonstrate excellent outcomes and suggest PBI is a feasible, safe alternative to WBI when SLNB is omitted.

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