Simultaneous Functional Ultrasound, Intrinsic Optical Signal and Widefield Calcium Neuroimaging
Mirg, S.; Gaddale, P.; Kumar, A.; Samanta, K.; Saini, B.; Patil, S. P.; Vargas, A. A.; Laliwala, A.; Exner, A. A.; Wang, Y.; Sipe, G. O.; Kothapalli, S.-R.
Show abstract
Functional ultrasound (fUS) maps cerebral blood volume (CBV) but lacks molecular and neuronal specificity. By simultaneously integrating fUS with optical imaging, we show that fUS-derived CBV correlates with both optically measured hemoglobin and neuronal calcium activity in awake mice. We further derive hemodynamic response functions linking calcium activity to CBV during spontaneous and sensory-evoked activity. Application to a mouse glioblastoma model demonstrates utility for studying neurovascular dysfunction in complex neuropathologies.
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