A Minimally Invasive, Suturable Platform for Brain Monitoring

Capturing infrequent or context dependent brain events, such as epileptic seizures and sleep abnormalities, often requires continuous monitoring over several days. It is most practical and scalable when achieved with unobtrusive, high-fidelity wireless systems that patients can use at home. Current electroencephalography systems restrict patient mobility and require continuous electrode maintenance and sub scalp solutions require surgical implantation that offer limited spatial coverage. We developed NeuroWeaves, gold polyimide microthreads thinner than a human hair that can be stitched through the epidermis using standard suture tools and connected to a lightweight wireless recorder. In preclinical models, NeuroWeaves captured whisker-evoked potentials with accuracy comparable to skull screws and matched the performance of a commercial acquisition benchmark. Semi-chronic recordings in freely moving animals remained stable for several weeks, and 30 day histology showed minimal inflammation comparable to surgical sutures. Pilot human studies reproduced posterior-dominant rhythms, photic responses, chewing artifacts, and sleep oscillations comparable to clinical electrodes. These results establish a minimally invasive, biocompatible neural interface that represents a new modality for high fidelity brain monitoring beyond conventional laboratory and clinical constraints.