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Fault-tolerant 3D reconstruction from 2D spatial proteomics sections

Zhang, Z.; Tan, Y.; Nolan, G.; Snyder, M.; Ma, Z.

2026-06-28 bioinformatics
10.64898/2026.06.23.733649 bioRxiv
Show abstract

Reconstructing 3D molecular volumes from sparsely sampled 2D tissue sections is limited by per-section marker dropout and tissue loss. We present 3D-Omics-Flow, a generative pipeline that jointly repairs damaged sections and interpolates between them at single-cell resolution. Across datasets spanning health and disease, 3D-Omics-Flow expands 3D spatial proteomics to practical sampling regimes, enabling atlas construction and downstream analysis from imperfect 2D section stacks.

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