NeuroEnergetics-on-Chip: a novel 3-compartment microfluidic platform to study metabolic interactions between brain parenchyma and cerebral vasculature
Ceballos Torres, A. P.; Montesi, L.; Loel, L.; Yanovska, M.; Venckute, J.; Jessika, J.; Wu, T.; Benito Zarza, L.; Cognetti, J.; Fotouhi, O.; Klavins, K.; Ygberg, S.; Wredenberg, A.; Wedell, A.; Herland, A.; Rogal, J.
Show abstract
Neurological disorders are a major cause of death and disability worldwide. The brain's energy metabolism is essential to its proper function, yet the mechanisms driving neuroenergetic dysfunction remain poorly understood. A key challenge is the limited availability of human-relevant models that can reproduce the complexity of brain physiology. An Organ-on-Chip (OoC) system was developed to mimic the neurovascular unit metabolic coupling by incorporating human isogenic iPSC-derived endothelial-like cells, pericyte-like cells, astrocytes, and a cerebral organoid, representing the main cellular components of the NVU. The novel, customized microfluidic platform enables research on neurovascular coupling by interconnecting a blood-brain barrier-on-a-chip model with a 3D brain parenchymal compartment to mimic physiological conditions.
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