Back

Re-evaluating the Cross-Sectional Prevalence of Severe Age-Related Hearing Loss Using Extreme Value Statistics

Bleeck, S.

2026-06-16 epidemiology
10.64898/2026.06.15.26355680 medRxiv
Show abstract

Standard demographic models of age-related hearing loss (presbycusis) predominantly utilize symmetric functions, such as log-normal distributions for age-binned thresholds and 4-parameter logistic curves for prevalence estimates. While these models capture early-to-moderate degradation effectively, they structurally struggle to characterize the heavy tails associated with severe clinical impairment. In this study, we present a statistical critique using a secondary analysis of the historical Medical Research Council (MRC) National Study of Hearing (1980-1986) dataset. By applying Generalized Extreme Value (GEV) distribution theory, we demonstrate that as severity increases, the underlying statistical geometry of hearing loss shifts. The asymmetric, heavy-tailed GEV distribution provides a parsimonious description of severe impairment, requiring fewer parameters than standard symmetric models. However, we explicitly acknowledge that utilizing static population data to infer progression introduces an ecological fallacy. Furthermore, the dataset's historical nature embeds unquantified generational cohort effects. We conclude that while extreme value statistics offer a compelling mathematical framework for modeling the variance of severe presbycusis, true longitudinal datasets are required to isolate physiological degradation from historical cohort variance.

Matching journals

The top 5 journals account for 50% of the predicted probability mass.

1
PLOS ONE
5266 papers in training set
Top 10%
18.8%
2
Hearing Research
54 papers in training set
Top 0.1%
12.1%
3
Scientific Reports
3612 papers in training set
Top 10%
6.8%
4
American Journal of Epidemiology
67 papers in training set
Top 0.1%
6.8%
5
PLOS Computational Biology
1863 papers in training set
Top 6%
5.6%
50% of probability mass above
6
Genetic Epidemiology
55 papers in training set
Top 0.1%
5.6%
7
Journal of The Royal Society Interface
235 papers in training set
Top 1%
4.1%
8
Proceedings of the National Academy of Sciences
2444 papers in training set
Top 19%
2.8%
9
Demographic Research
11 papers in training set
Top 0.1%
2.7%
10
Journal of Theoretical Biology
162 papers in training set
Top 1%
2.5%
11
Frontiers in Neurology
102 papers in training set
Top 1%
2.4%
12
eLife
5828 papers in training set
Top 53%
1.5%
13
PNAS Nexus
159 papers in training set
Top 1%
1.4%
14
Trends in Hearing
15 papers in training set
Top 0.2%
1.1%
15
Royal Society Open Science
214 papers in training set
Top 4%
1.1%
16
Statistics in Medicine
40 papers in training set
Top 0.5%
1.1%
17
PLOS Genetics
862 papers in training set
Top 11%
0.9%
18
Philosophical Transactions of the Royal Society B: Biological Sciences
72 papers in training set
Top 2%
0.9%
19
BMC Medical Research Methodology
47 papers in training set
Top 1%
0.9%
20
Epidemics
116 papers in training set
Top 2%
0.9%
21
Epidemiology
32 papers in training set
Top 0.7%
0.6%
22
Nature Communications
5641 papers in training set
Top 59%
0.6%
23
European Journal of Epidemiology
43 papers in training set
Top 0.9%
0.6%
24
International Journal of Epidemiology
88 papers in training set
Top 2%
0.6%