Tunneling nanotubes mediate mitochondrial homeostasis in cancer
Saenz-de-Santa-Maria, I.;Pepe, A.;Brou, C.;Tinevez, J.;Vitrenko, Y.;Cokelaer, T.;Moyal, E.;Weigert, R.;Zurzolo, C.
Show abstract
Tumor progression is driven by cancer cells ability to establish a cellular network through tunneling nanotube-like connections (TNTs), which enable mitochondrial exchange both within the tumor cells and with the tumor microenvironment (TME). However, the effects of mitochondrial transfer between tumor and non-tumor cells, and its occurrence in vivo, remain poorly understood. In this study, we demonstrate bidirectional mitochondrial transfer: damaged mitochondria from Glioblastoma (GBM) cells trigger mitophagy in non-tumoral astrocytes (AS), while healthy mitochondria from AS enhance the metabolic activity of GBM cells. Furthermore, intravital subcellular microscopy (ISMic) in a live animal model, allowed the visualization of TNT connections with characteristics similar to those observed in vitro and supported TNT-mediated mitochondrial transfer in vivo. These findings provide critical insights into TME interactions and their contribution to cancer resilience, highlighting TNTs as a potential target for therapeutic intervention and paving the way for further research into their role in cancer.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Mitochondrial metabolism sustains CD8+ T cellmigration for an efficient infiltration into solid tumors 96%
- Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells 95%
- Self-organizing glycolytic waves fuel cell migration and cancer progression 94%
Similar papers in this journal
- Mieap forms membraneless organelles to compartmentalize and facilitate cardiolipin metabolism 95%
- Reversible Dissociation of Mitochondrial Complex V Balances Anabolic and Energy-Generating Needs in Cancer 94%
- Multilevel Plasticity and Altered Glycosylation Drive Aggressiveness in Hypoxic and Glucose-Deprived Bladder Cancer Cells 93%
Similar papers in this journal
- Laterally transferred macrophage mitochondria acts as a signaling source promoting cancer cell proliferation 94%
- Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction 93%
- Syncytin-mediated open-ended membrane tubular connections facilitate the intercellular transfer of cargos including Cas9 protein 93%
Similar papers in this journal
- Automated live-cell single-molecule tracking in enteroid monolayers reveals transcription factor dynamics probing lineage-determining function 95%
- Transcriptional Control of Brain Tumour Stem Cell by a Carbohydrate Binding Protein 94%
- P-cadherin mechanoactivates tumor- mesothelium metabolic coupling to promote ovarian cancer metastasis 94%
Similar papers in this journal
- ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism. 94%
- Invadopodia enable cooperative invasion and metastasis of breast cancer cells 94%
- GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.