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GSPlot: Visualizing gene set similarity in enrichment results

Le, T.;Espinoza, C.;Courtois, J.;Babur, O.

2026-06-16 Systems Biology
10.64898/2026.06.11.731691 bioRxiv
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SummaryInterpretation of gene set enrichment analyses is challenging when the results contain many sets. Similarities in those sets can be used for complexity management. We present GSPlot, a web-based application for visualizing enrichment results of large gene set collections. GSPlot displays gene sets in a two-dimensional space where distances reflect the similarity of their enriched content. This view brings a higher-level structure to the enrichment results and simplifies their interpretation and communication. Availability and implementationGSPlot is available at https://gsplot.cs.umb.edu/. Source code is available at https://github.com/PathwayAndDataAnalysis/gsplot.

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