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STN-DBS frequency-tuned beta subband dynamics are associated with speech tempo in Parkinson's disease

Tian, H.; Wu, Y.; Fan, Y.; Yin, Z.; Guo, Y.; Meng, F.; Zhang, J.; Yu, H.; Li, L.

2026-06-10 neuroscience
10.64898/2026.06.07.729490 bioRxiv
Show abstract

In Parkinsons disease, subthalamic nucleus deep brain stimulation (STN-DBS) frequency modulates narrow beta subbands, with low-frequency stimulation (LFS) selectively attenuating 15-23 Hz power. The negative association between this subband and speech tempo, together with the LFS-related improvement in articulatory rate, suggests that 15-23 Hz subband dynamics may serve as a candidate neural marker associated with speech tempo modulation.

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