Antifungal tolerance and resistance dynamics depend on infection load, drug treatment, and host innate immunity
Galon, C. M.; Charlebois, D. A.
Show abstract
Fungi contribute substantially to the global antimicrobial resistance crisis. Tolerance is a novel form of antifungal resistance in which fungal pathogens emerge, grow slowly, and survive antifungal drug treatment. We quantitatively model the population and evolutionary dynamics of a multidrug resistant pathogen Candidozyma auris (formerly Candida auris) infecting an invertebrate host (Galleria mellonella) with an innate immune system. We find that the establishment, dominance, and co-existence of tolerant and resistant subpopulations depend on infection load, drug-treatment, and innate host immunity. This study enhances our understanding of the population and evolutionary dynamics of pathogenic infections and provides a quantitative framework to predict antimicrobial resistance.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A stochastic analysis of the interplay between antibiotic dose, mode of action, and bacterial competition in the evolution of antibiotic resistance 95%
- Aggressive or moderate drug therapy for infectious diseases? Trade-offs between different treatment goals at the individual and population levels 95%
- An antigenic diversification threshold for falciparum malaria transmission at high endemicity 95%
Similar papers in this journal
- Interventions targeting nonsymptomatic cases can be important to prevent local outbreaks: SARS-CoV-2 as a case-study 94%
- Dynamic mean and variance of microparasite load give key insights into population dynamics and underlying mechanisms 94%
- Will an outbreak exceed available resources for control? Estimating the risk from invading pathogens using practical definitions of a severe epidemic 94%
Similar papers in this journal
Similar papers in this journal
- Impact of resistance on therapeutic design: a Moran model of cancer growth 93%
- Modelling Immune Dynamics in Locally Advanced MSI-H/dMMR Colorectal Cancer with Neoadjuvant Pembrolizumab Treatment: From Differential Equations to an Agent-Based Framework 93%
- Mathematical modeling to guide experimental design: T cell clustering as a case study 93%
Similar papers in this journal
- Behavioral response of insecticide-resistant mosquitoes against spatial repellent: a modified self-propelled particle model simulation 93%
- Is increased mortality by multiple exposures to COVID-19 an overseen factor when aiming for herd immunity? 93%
- Effect of resistant compartment on pathogen strategy in partially migratory populations 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.