From the scanner to daily life: Neural expression of the Picture-Induced Negative Emotion Signature is associated with real-world daily and momentary negative affect in midlife adults
Wu-Chung, E. L.; Eckerle, W. D.; Marsland, A. L.; Kraynak, T. E.; Kamarck, T. W.; Gianaros, P. J.
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Functional magnetic resonance imaging (fMRI) is widely used to map brain systems that process affective stimuli and predict concurrent affective experiences in the scanner. However, the extent to which affect-related fMRI activity in the scanner predicts affective experiences in daily life remains unclear. This study examined whether a multivariate brain pattern previously validated to predict negative affect to emotional images during fMRI testing (the Picture-Induced Negative Emotion Signature; PINES) associates with daily negative affect measured over 7-10 days via daily diaries and ecological momentary assessment. Among 287 midlife adults, those exhibiting greater PINES pattern expression showed greater daily (end-of-day) and hourly negative affect. These findings were not explained by demographic factors and trait negative affect. A cross-validated whole-brain pattern of negative affect generalizes beyond the fMRI testing context to predict negative affect severity in daily life.
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