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Ageing blunts the phospho-proteomic response to resistance exercise in humans

Palmer, A. S.; Alldritt, I.; Apro, W.; Huckstep, H.; Horwath, O.; Le, L.; Cree, T.; Deemer, S.; Watson, E.; Mills, R.; Humphrey, S. J.; Philp, A.

2026-06-05 physiology
10.64898/2026.06.02.729449 bioRxiv
Show abstract

Ageing blunts the adaptive growth response in human skeletal muscle. To define the molecular processes underlying this impairment, we performed unbiased analysis of the phosphoproteome and total proteome in healthy young and old human skeletal muscle following acute resistance exercise (ResEX) and essential amino acid (EAA) ingestion. Ageing led to global suppression of the growth-induced global phosphoproteome, despite intact mTORC1 activation in old muscle. Our results identify widespread effects of ageing on skeletal muscle growth and highlight novel pathways for therapeutic development in aged skeletal muscle.

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