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VOGeo-Gaze: Calibration-Free, Geometry-Aware Deep Learning for Real-Time Gaze Tracking in Clinical Video-Oculography

Zhao, J.; Ahmadi, S.-A.; Decker, J.; Zwergal, A.; Eulenburg, P. z.; Flanagin, V. L.; Wuehr, M.

2026-05-29 health informatics
10.64898/2026.05.27.26354254 medRxiv
Show abstract

Quantitative eye movement analysis is important for neuro- logical diagnostics, yet existing video-oculography (VOG) systems typ- ically require calibration, device-specific settings, or accurate gaze la- bels. We present VOGeo-Gaze, a real-time, calibration-free, geometry- aware neural network that estimates gaze by reconstructing anatomi- cally meaningful eyeball parameters from image features. The method combines segmentation-driven projection geometry, a refraction-aware pupil correction module, and temporal anatomical stabilization, so gaze is derived from interpretable eye geometry rather than direct angular regression. Trained only on the public TEyeD dataset with weak gaze supervision, VOGeo-Gaze was evaluated on 116 clinical recordings from 17 patients and 19 healthy subjects using EyeSeeCam, a clinical gold- standard VOG system. It achieved median absolute angular errors of 0.33{whitebullet} horizontally and 0.35{whitebullet} vertically, with nearly 92% of recordings below 1{whitebullet} error while operating at >300 FPS. These results demonstrate sub-degree clinical gaze estimation without subject-specific calibration, camera intrinsics, or accurate gaze labels, providing a scalable and inter- pretable alternative to conventional VOG pipelines. Code is available at https://github.com/DSGZ-MotionLab/VOGeo-Gaze.

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