Maternal immunity, cesarean delivery, and childhood neuropsychiatric risk in 1.18 million births
Kramer, B.; Kushner, S. A.; Rzhetsky, A.
Show abstract
Maternal infection, immune disease, and delivery mode are plausible influences on early brain development. We analyzed 1,179,611 US Merative MarketScan mother-child pairs (2003-2024), including 259,339 non-twin siblings in 123,926 families. Population models screened 18 perinatal exposures against 13 childhood psychiatric/neurodevelopmental diagnosis-count outcomes; sibling fixed effects tested robustness to stable family-level confounding. Cesarean delivery was associated with higher composite neurodevelopmental diagnosis counts in pairs (23.4%) and siblings (25.0%) and with ADHD in siblings (38.8%; FDR q = 0.025). Autism was elevated in pairs (20.0%) but not supported within families (5.0%; p = 0.87). Claims-defined no-labor/no-repeat cesarean showed stronger lower-risk-birth associations for composite neurodevelopmental burden (48.0%), autism (44.9%), speech/language disorders (41.0%), and ADHD (24.1%). Maternal infection/immune-mediated disease, preterm birth, and advanced maternal age were additional population signals.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Decomposition of phenotypic heterogeneity in autism reveals distinct and coherent genetic programs 95%
- Rare coding variation illuminates the allelic architecture, risk genes, cellular expression patterns, and phenotypic context of autism 95%
- Polygenic profiles define aspects of clinical heterogeneity in ADHD 95%
Similar papers in this journal
- Identification of 64 new risk loci for major depression, refinement of the genetic architecture and risk prediction of recurrence and comorbidities 95%
- Multi-ancestry study of the genetics of problematic alcohol use in >1 million individuals 94%
- Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19 93%
Similar papers in this journal
- Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism 94%
- Genetic variants associated with cross-disorder and disorder-specific risk for psychiatric disorders are enriched at epigenetically active sites in peripheral lymphoid cells 94%
- Systematic analysis and prediction of genes associated with disorders on chromosome X 94%
Similar papers in this journal
- Genome-wide prediction of dominant and recessive neurodevelopmental disorder risk genes 95%
- The relationship between genotype- and phenotype-based estimates of genetic liability to psychiatric disorders, in practice and in theory. 94%
- ExPRSweb - An Online Repository with Polygenic Risk Scores for Common Health-related Exposures 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.