Distinct Resting-State Functional Connectivity Profiles in ADHD with and without Prenatal Alcohol Exposure
Gupta, I.; Farkouh, L.; Kilpatrick, L. A.; Korthas, J.; Salamon, N.; Schneider, B. N.; Joshi, S. H.; Alger, J. R.; O'Connor, M. J.; O'Neill, J.
Show abstract
Aim: To determine whether the neural phenotype (whole-brain resting-state functional connectivity pattern) of attention deficit hyperactivity disorder associated with prenatal alcohol exposure (ADHD+PAE) differs from that in unexposed children with ADHD of probable familial origin (ADHD-PAE). Method: Resting-state functional MRI was acquired from 26 children with ADHD+PAE, 25 with ADHD-PAE, and 25 typically developing (TD) children, all aged 8-13 years. Mean connectivity matrices based on the Cole-Anticevic Brainwide Network Parcellation of the brain were compared between the groups. Results: Within the frontoparietal network (FPN), children with ADHD+PAE showed widespread lower group-mean connectivity than children with ADHD-PAE; effects were concentrated primarily in cerebellar-cerebral cortical and cerebral cortical-cerebral cortical connections. Children with ADHD-PAE showed widespread hyperconnectivity relative to TD children. Children with ADHD+PAE showed mixed hyper- and hypoconnectivity relative to TD. Interpretation: These results are consistent with other MRI findings indicating that ADHD+PAE is neurally distinct from ADHD-PAE; PAE may be associated with broadly reduced connectivity, especially across cerebellar-cerebral cortical systems.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Structural Brain Alterations and Their Association with Cognitive Function and Symptoms in Attention-Deficit/Hyperactivity Disorder Families 96%
- Exploring the longitudinal associations of functional network connectivity and psychiatric symptom changes in youth 95%
- Clarifying the role of Cortico-Cortical and Amygdalo-Cortical brain dysconnectivity associated with Conduct Problems 95%
Similar papers in this journal
- Identifying Developmental Changes in Functional Brain Connectivity Associated with Cognitive Functioning in Children and Adolescents with ADHD 95%
- Delineating disorder-general and disorder-specific dimensions of psychopathology from functional brain networks in a developmental clinical sample 95%
- Longitudinal white matter development in children is associated with puberty, attentional difficulties, and mental health 93%
Similar papers in this journal
- White matter connectivity of uncinate fasciculus and inferior fronto-occipital fasciculus: A possible early biomarker for callous-unemotional behaviors in young children with ADHD 96%
- Transdiagnostic Profiles of Behaviour and Communication Relate to Academic and Socio-emotional Functioning and Neural White Matter Organisation 95%
- Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes 94%
Similar papers in this journal
- Testing the sensitivity of diagnosis-derived patterns in functional brain networks to symptom burden in a Norwegian youth sample 95%
- Altered brain morphology in boys with attention-deficit/hyperactivity disorder with and without comorbid conduct disorder/oppositional defiant disorder 95%
- Effects of a single-dose methylphenidate challenge on resting-state functional connectivity in stimulant-treatment naive children and adults with ADHD 94%
Similar papers in this journal
- BOLD differences normally attributed to inhibitory control predict symptoms, not task-directed inhibitory control in ADHD 94%
- Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD 93%
- Reduced Lateralization of Multiple Functional Brain Networks in Autistic Males 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.