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One-pot enzymatic synthesis of the sugar nucleotide CDP-ribitol

Akkad, S.; Wan, E. W.; Maddison, A.; Rule Mcloughlin, J.; Au-Yeung, C.; Murphy, L. D.; Willems, L. I.

2026-05-24 biochemistry
10.64898/2026.05.22.727167 bioRxiv
Show abstract

CDP-ribitol serves as an essential donor for D-ribitol-5-phosphate incorporation into bacterial and mammalian glycoconjugates. Here, we demonstrate the one-pot enzymatic synthesis of CDP-ribitol from the readily available precursor ribitol. We also explore the synthesis of bioorthogonally tagged derivatives and other CDP conjugates, thereby providing valuable new tools for glycoscience research.

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