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Ibrutinib modulates CD19 expression and improves efficacy of CD19-CAR T cells in B-cell lymphoma models

Wang, S.; Arribas, A. J.; Tarantelli, C.; Civanelli, E.; Zhou, G.; Purwar, P.; Pradier, A.; Melotti, A.; Guidetti, F.; Hajj Younes, Y.; Terzi Di Bergamo, L.; Cascione, L.; Napoli, S.; Zucca, E.; Sotillo, E.; Mackall, C.; Esteller, M.; Chalandon, Y.; Rossi, D.; Simonetta, F.; Bertoni, F.

2026-05-26 immunology
10.64898/2026.05.22.727139 bioRxiv
Show abstract

Antigen density critically influences CAR T-cell efficacy. We show that ibrutinib induces CD19 upregulation in B-cell lymphoma models, enhancing CAR T-cell cytotoxicity. Pharmacologic modulation of target antigen expression represents a promising strategy to overcome resistance.

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