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Growth bistability in small bacterial populations exposed to antibiotics

Ledoux, B.; Lacoste, D.

2026-05-23 biophysics
10.64898/2026.05.21.726888 bioRxiv
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With the development of microfluidics, it has now become possible to assess the susceptibility of bacteria to antibiotics at the single-cell level instead of relying on population measurements. Such studies are particularly relevant when the growth of bacterial population in the presence of antibiotics is heterogeneous. Here, we build a model to describe such a case, and apply it to experimental measurements on a small population of E. Coli exposed to ciprofloxacin, a drug which is well known for triggering a bistable response.

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