Colletotrichum higginsianum effector ChEC108 binds a plasmodesmal HMA protein and elicits plant defence
Turley, E. K.; Yu, D. S.; Breakspear, A.; Jennings, J.; Bautista, M.-J. A.; Jones, S.; Ravi, B.; Zdrzalek, R.; Ma, W.; Bentham, A. R.; Ryder, L.; Talbot, N. J.; Banfield, M. J.; Faulkner, C.
Show abstract
To establish infection, phytopathogens deploy effectors to compromise host defences and facilitate invasive growth. As part of this, the battle for control of symplastic connectivity via plasmodesmata is a key determinant of infection outcomes, yet little is known about how fungal effectors directly exploit these channels, and in turn, how hosts defend them. Here, we have identified ChEC108 as a plasmodesmal-targeting, cell-to-cell mobile effector from the anthracnose fungus, Colletotrichum higginsianum. ChEC108 binds the plasmodesmal protein HEAVY METAL-ASSOCIATED (HMA) ISOPRENYLATED PLANT PROTEIN 6 (HIPP6) from Arabidopsis via a tetrahedral metal ion coordination site with either of its HMA domains. Constitutive in planta expression of ChEC108 induces plasmodesmal closure and the upregulation of defence-associated genes in a manner dependent on its capacity to bind HIPP6. Further, HIPP6 binding impairs cell-to-cell mobility of ChEC108. Alongside the finding that loss of ChEC108 favoured C. higginsianum infection, this suggests ChEC108-HIPP6 interaction at plasmodesmata positively regulates defence.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The blast effector Pwl2 is a virulence factor that modifies the cellular localisation of host protein HIPP43 to suppress immunity. 97%
- Bioengineering secreted proteases converts divergent Rcr3 orthologs and paralogs into extracellular immune co-receptors 96%
- The Medicago truncatula DREPP protein triggers microtubule fragmentation in membrane nanodomains during symbiotic infections 96%
Similar papers in this journal
- RPG acts as a central determinant for infectosome formation and cellular polarization during intracellular rhizobial infections 97%
- An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species 97%
- Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula 96%
Similar papers in this journal
Similar papers in this journal
- The Ralstonia solanacearum effector RipAV targets Plant U-box proteins and induces proteasomal-dependent degradation of BIK1 96%
- Cell-type specific gating of gene regulatory modules as a hallmark of early immune responses in Arabidopsis leaves 95%
- Arabidopsis PROTODERMAL FACTOR2 binds lysophosphatidylcholines and transcriptionally regulates phospholipid metabolism 95%
Similar papers in this journal
- Directed growth and fusion of membrane-wall microdomains requires CASP-mediated inhibition and displacement of secretory foci 96%
- Evolutionary Origins and Functional Diversification of Auxin Response Factors 96%
- The Botrytis cinerea Crh transglycosylae is a cytoplasmic effector triggering plant cell death and defense response 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.