UT-018 Accelerates Wound Repair and Hair Follicle Regeneration in Murine Models
Saxena, U.; K, S.; Jadhav, P.; Shahapur, S.; Mehboob, S.; Kadiyala, G.; Gorantla, M.
Show abstract
UT-018, a stem cell chemoattractant formulation, demonstrated significant regenerative activity across independent murine wound-healing and hair-regeneration studies. Topical treatment accelerated wound closure, enhanced granulation tissue formation, improved collagen organization, increased fibroblast proliferation, and enhanced dermal vascularization. Separate hair-growth studies demonstrated increased follicular density, deeper follicular penetration, enhanced dermal vascularization, and induction of anagen-phase transition by UT-018. Mechanistic studies demonstrated strong intracellular cAMP generation and activation-associated {beta}-catenin phosphorylation consistent with GPCR-mediated regenerative signaling.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.