The Biodiversity of Africa in the Digital Genomics Era: A Systematic Analysis of Institutional Gaps and Benefit-Sharing Trajectories under the Cali Fund.

BackgroundA structural governance failure sits at the intersection of international biodiversity law and the digital genomics revolution. The Convention on Biological Diversity (CBD) and the Nagoya Protocol on Access and Benefit-Sharing (ABS) were designed to ensure that countries of biological origin share equitably in commercial benefits from their genetic resources. Critically, these instruments apply exclusively to non-human genetic resources: plants, animals, fungi, and microbiota. Human genetic resources are deliberately excluded from the CBD and Nagoya ABS framework and are governed separately through bioethics instruments, including the World Health Organization (WHO) framework and the Declaration of Helsinki. This study focuses on non-human digital sequence information (DSI), nucleotide and protein sequence data derived from non-human organisms deposited in open-access databases, which underpins industries generating over USD 1.56 trillion in annual revenue. Africa, hosting approximately 25% of global terrestrial species and nine of the worlds 36 biodiversity hotspots, provides a disproportionate share of the genetic resources from which non-human DSI is derived, yet receives negligible monetary returns because digitisation severs the traceability chain that ABS governance requires. Human genomic data is presented here solely as a secondary indicator of Africas broader infrastructure; it does not constitute the legal basis for Africas modelled allocation share under the Cali Fund. ObjectivesThis study systematically characterises (i) Africas non-human biodiversity endowment as the basis for Cali Fund claims; (ii) ABS governance readiness across 54 African Union (AU) member states; (iii) the commercial trajectories of non-human DSI-dependent industries and projected Cali Fund benefit-sharing flows; and (iv) Africas human genomic representation as a secondary infrastructure indicator, explicitly distinguished from the non-human DSI benefit-sharing argument. MethodsA structured evidence synthesis was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 reporting elements, where applicable to a secondary data analysis design. Literature was searched across PubMed, Scopus, Web of Science, Google Scholar, and official repositories of the CBD, Food and Agriculture Organization of the United Nations (FAO), International Union for Conservation of Nature (IUCN), and United Nations Environment Programme (UNEP). The search was restricted to January 2022 - April 2026 to capture post-Kunming-Montreal Global Biodiversity Framework (KMGBF) literature. A total of 412 records were identified before screening; 34 peer-reviewed articles and 19 institutional documents met all inclusion criteria. Quantitative Cali Fund scenario modelling used the United Nations Environment Programme World Conservation Monitoring Centre (UNEP-WCMC) and KPMG (2024) non-human DSI sector revenue baseline (CBD/WGDSI/2/2/Add.2). The 12.5% net profit margin is a cross-sector proxy from that study; actual margins vary by sector. Africas modelled allocation share (20-25%) is the authors analytical construct based on Africas non-human species richness and hotspot share; it is not an internationally agreed formula. ResultsAfricas non-human biodiversity endowment is exceptional: 25% of terrestrial species, nine of 36 biodiversity hotspots, and the worlds second-largest tropical forest system. Non-human DSI from African genetic resources is a critical input to industries generating USD 1.56 trillion annually, yet Africa contributes a marginal and unmeasured fraction of International Nucleotide Sequence Database Collaboration (INSDC) sequences. As a secondary indicator, 94.48% of genome-wide association study (GWAS) participants as of 2024 were of European ancestry (Corpas et al., 2025); this human genomic data is presented for contextual illustration only and is not the basis for Africas Cali Fund modelled allocation share. Zero African Union member states have enacted legislation explicitly covering non-human DSI in their ABS framework. Africas modelled allocation share ranges from USD 312 million (Scenario A, 20% weight) to USD 5.83 billion (Scenario C, 25% weight) annually. ConclusionsAfrica is among the most biologically rich continents on Earth for non-human life, yet structurally excluded from the benefit-sharing framework the CBD intended to create. The Cali Fund represents the first mechanism capable of correcting this at scale. Realising Africas modelled allocation share requires urgent legislative reform, institutional capacity investment, sequencing infrastructure development, and a coordinated African position at COP17 scheduled in Yerevan, October 2026.