Back

Precision Physical Activity Prescription via Reinforcement Learning for Functional Actions

Lin, G.; Miao, R.; Sacheck, J.; Zhang, X.

2026-05-21 public and global health
10.64898/2026.05.18.26353525 medRxiv
Show abstract

Physical activity (PA) plays an important role in maintaining and improving health. Daily steps have been a key PA measure that is easily accessible with common wearable devices. However, methods are lacking to recommend a personalized optimal distribution of daily steps over a period of time for the best of certain health biomarkers. In this paper, we fill this void based on the data from the All of Us Research Program which includes months of step counts as well as repeated measurements of key health biomarkers. We develop a new offline reinforcement learning (RL) algorithm to learn personalized and optimal PA distributions associated with cardiometabolic risk, where the action is a function representing the daily step distribution over a period of time. Simulation studies demonstrate the advantage of the proposed approach over existing continuous-action RL methods. The learned optimal policy from the All of Us data generally suggests people take more daily steps and also follow a more consistent pattern of PA over time while offering tailored recommendations for subgroups in blood glucose level, body mass index, blood pressure, age, and sex.

Matching journals

The top 8 journals account for 50% of the predicted probability mass.

1
npj Digital Medicine
118 papers in training set
Top 0.3%
18.4%
2
PLOS ONE
5266 papers in training set
Top 22%
7.8%
3
Nature Communications
5641 papers in training set
Top 24%
6.7%
4
Scientific Reports
3612 papers in training set
Top 17%
5.4%
5
International Journal of Obesity
29 papers in training set
Top 0.2%
4.0%
6
eLife
5828 papers in training set
Top 36%
3.2%
7
PLOS Computational Biology
1863 papers in training set
Top 11%
2.8%
8
Journal of Medical Internet Research
87 papers in training set
Top 1%
2.4%
50% of probability mass above
9
Statistical Methods in Medical Research
11 papers in training set
Top 0.1%
2.4%
10
IEEE Access
35 papers in training set
Top 0.5%
2.4%
11
Journal of Biomedical Informatics
47 papers in training set
Top 0.7%
2.1%
12
Frontiers in Physiology
106 papers in training set
Top 0.9%
2.1%
13
Frontiers in Neuroscience
256 papers in training set
Top 3%
1.9%
14
Proceedings of the National Academy of Sciences
2444 papers in training set
Top 28%
1.7%
15
International Journal of Behavioral Nutrition and Physical Activity
15 papers in training set
Top 0.2%
1.7%
16
Statistics in Medicine
40 papers in training set
Top 0.4%
1.5%
17
Journal of the American Medical Informatics Association
71 papers in training set
Top 2%
1.3%
18
Expert Systems with Applications
11 papers in training set
Top 0.2%
1.3%
19
Journal of Neural Engineering
221 papers in training set
Top 2%
1.3%
20
PLOS Digital Health
106 papers in training set
Top 3%
1.1%
21
Frontiers in Public Health
148 papers in training set
Top 5%
1.1%
22
IEEE Journal of Biomedical and Health Informatics
37 papers in training set
Top 1%
1.0%
23
National Science Review
21 papers in training set
Top 0.2%
1.0%
24
npj Systems Biology and Applications
125 papers in training set
Top 2%
0.9%
25
Communications Medicine
113 papers in training set
Top 5%
0.8%
26
JMIR Public Health and Surveillance
45 papers in training set
Top 2%
0.8%
27
Journal of NeuroEngineering and Rehabilitation
36 papers in training set
Top 0.7%
0.8%
28
Applied Sciences
25 papers in training set
Top 0.9%
0.8%
29
iScience
1154 papers in training set
Top 40%
0.6%
30
Biostatistics
24 papers in training set
Top 0.4%
0.6%