Back

Composite Certainty: Addressing Metric Degeneracy in Parameter Inference for Model-Based Diagnostics

Koshe, A.; Sobhani Tehrani, E.; Jalaleddini, K.; Motallebzadeh, H.

2026-05-13 bioengineering
10.64898/2026.05.09.724027 bioRxiv
Show abstract

Quantifying the diagnostic dispersion of inferred parameter distributions is a challenge in uncertainty-aware modeling. Scalar summaries such as credible interval width are topology-blind; fundamentally different posterior morphologies can yield identical scores, obscuring whether a parameter is precisely estimated or constrained to a range. We propose a Composite Certainty Framework that addresses this metric degeneracy by aggregating five complementary uncertainty metrics including interquartile range, standard deviation, full width at half maximum, Shannon entropy, and mass width. These metrics are aggregated through non-parametric Borda rank voting into a single, unitless consensus certainty score. Applied to a simulation-based inference pipeline for a finite-element model of the human middle ear tuned to cadaveric acoustic measurements, the framework reveals parameter-specific identifiability profiles invisible to any individual metric. It produces two actionable clinical thresholds: (1) the maximum tolerable measurement noise for reliable parameter recovery, and (2) the minimum simulation budget for posterior convergence. We demonstrated that no single metric captures all aspects of posterior dispersion, as spread-based metrics and entropy diverge systematically for clinically critical parameters, whereas their aggregation produces a consensus reflecting genuine diagnostic certainty. The framework is generalizable to any model-based diagnostic pipeline where posterior distribution not merely its coverage, but determines clinical certainty.

Matching journals

The top 7 journals account for 50% of the predicted probability mass.

1
PLOS Computational Biology
1633 papers in training set
Top 2%
14.2%
2
PLOS ONE
4510 papers in training set
Top 19%
10.0%
3
IEEE Transactions on Medical Imaging
18 papers in training set
Top 0.1%
8.3%
4
Journal of The Royal Society Interface
189 papers in training set
Top 0.5%
6.7%
5
Nature Communications
4913 papers in training set
Top 36%
4.3%
6
Epidemics
104 papers in training set
Top 0.5%
3.5%
7
Scientific Reports
3102 papers in training set
Top 38%
3.5%
50% of probability mass above
8
Philosophical Transactions of the Royal Society B
51 papers in training set
Top 2%
3.0%
9
IEEE Transactions on Biomedical Engineering
38 papers in training set
Top 0.3%
2.7%
10
Nature Methods
336 papers in training set
Top 3%
2.6%
11
Proceedings of the National Academy of Sciences
2130 papers in training set
Top 26%
2.4%
12
Science Advances
1098 papers in training set
Top 12%
2.3%
13
Computers in Biology and Medicine
120 papers in training set
Top 2%
2.1%
14
eLife
5422 papers in training set
Top 38%
1.9%
15
Advanced Science
249 papers in training set
Top 10%
1.8%
16
Cell Systems
167 papers in training set
Top 7%
1.7%
17
Science Translational Medicine
111 papers in training set
Top 3%
1.7%
18
npj Digital Medicine
97 papers in training set
Top 2%
1.6%
19
Human Brain Mapping
295 papers in training set
Top 3%
1.3%
20
Annals of Biomedical Engineering
34 papers in training set
Top 0.9%
1.2%
21
Journal of Neural Engineering
197 papers in training set
Top 1%
1.2%
22
Nature Machine Intelligence
61 papers in training set
Top 3%
1.2%
23
Nature Biomedical Engineering
42 papers in training set
Top 1%
1.2%
24
IEEE Access
31 papers in training set
Top 0.7%
0.9%
25
iScience
1063 papers in training set
Top 27%
0.9%
26
Computer Methods and Programs in Biomedicine
27 papers in training set
Top 0.9%
0.8%
27
Biophysical Journal
545 papers in training set
Top 5%
0.8%
28
Communications Biology
886 papers in training set
Top 22%
0.8%
29
International Journal for Numerical Methods in Biomedical Engineering
12 papers in training set
Top 0.2%
0.7%
30
Development
440 papers in training set
Top 4%
0.7%