Label-free quantitative 3D mapping of collagen architecture by holotomography
Lee, S.; Park, W. S.; Lee, J.; Park, J.; Park, H.; Ahn, E. H.; Kim, D.-H.; Park, Y.
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Quantitative label-free analysis of collagen architecture lacks physically calibrated volumetric methods. Here we present holotomography (HT), which reconstructs three-dimensional refractive-index (RI) distributions of collagen networks. Because RI scales linearly with dry mass density, HT yields fiber-level morphology and mass from a single acquisition. HT resolves 3D fibrillar structure, distinguishes subtype-specific organizational and mass differences, and tracks polymerization and cell-driven remodeling, establishing a quantitative framework for extracellular matrix analysis.
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