A threonine-to-aspartate ACA codon reassignment in uncultivated Acidimicrobiales bacteria
Fakih, F.; Shulgina, Y.; Lukes, J.; Butenko, A.
Show abstract
The list of alternative genetic codes continues to grow, yet sense-to-sense codon reassignments remain very rare. Here we analyze a new sense-to-sense codon reassignment in bacteria, where the ACA codon, which canonically specifies threonine, has been predicted to encode aspartate. This so far unprecedented genetic code alteration is confined to a clade within the RAAP-2 family of the order Acidimicrobiales (phylum Actinomycetota). Validated by multiple alignments of highly conserved proteins, the reassignment is further supported by the presence of a tRNAUGU that lacks the G1:C72 threonylation identity element, suggesting that this tRNA is charged with aspartate instead of threonine. Our findings not only expand the set of known natural departures from the canonical genetic code by a novel type of sense-to-sense reassignment but also implicate the ACA codon that was so far considered invariably conserved in its meaning.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Dynamics of diversified A-to-I editing in Streptococcus pyogenes is governed by changes in mRNA stability 96%
- tRNAscan-SE 2.0: Improved Detection and Functional Classification of Transfer RNA Genes 96%
- Evolutionary repair reveals an unexpected role of the tRNA modification m1G37 in aminoacylation 96%
Similar papers in this journal
- Selection for reducing energy cost of protein production drives the GC content and amino acid composition bias in gene transfer agents 97%
- Diversity, Origin and Evolution of the ESCRT Systems 96%
- Conservation and evolution of the programmed ribosomal frameshift in prfB across the bacterial domain 96%
Similar papers in this journal
- Inferring gene-pathway associations from consolidated transcriptome datasets: an interactive gene network explorer for Tetrahymena thermophila 94%
- Rapid discovery of novel prophages using biological feature engineering and machine learning 93%
- Nuclease genes occupy boundaries of genetic exchange between bacteriophages 93%
Similar papers in this journal
- The compact genome of Giardia muris reveals important steps in the evolution of intestinal protozoan parasites 94%
- Gene-gene relationships in an Escherichia coli accessory genome are linked to function and mobility 94%
- Co-transfer of functionally interdependent genes contributes to genome mosaicism in lambdoid phages 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.