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Neural signatures of real-world turning during naturalistic locomotion in Parkinson's Disease

Ramesh, R.; Balakid, J.; Marks, J. H.; Louie, K. H.; Song, S.; Shukla, P.; Fekri Azgomi, H.; Wang, D. D.

2026-05-05 neurology
10.64898/2026.05.03.26352320 medRxiv
Show abstract

Turning is a complex motor behavior that frequently triggers freezing of gait and falls in Parkinsons disease (PD), yet its neural dynamics in naturalistic settings remain unknown. Using chronic at-home intracranial recordings in four subjects with PD, we show that turning is marked by premotor cortical beta desynchronization driven by reduced burst rate. These findings identify a robust signature of ecological turning and implicate beta dynamics in adaptive motor transitions.

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