One-Year Brain Structural Changes Are Associated with Postoperative Delirium and Delayed Resolution of Interleukin-6
Lv, J.; Taylor, J.; Curtis, S.; Kramer, K.; Kunkel, D.; Thakur, S.; Nair, V.; Banks, M. I.; Pearce, R. A.; Prabhakaran, V.; Lennertz, R.; Sanders, R. D.
Show abstract
BackgroundPostoperative delirium is a common complication in older adults and is associated with neuroinflammation and cognitive decline. Previous studies have shown that the number of surgical procedures is associated with hippocampal volume loss in older adults in a large-scale UK Biobank study. However, it remains unclear whether hippocampal volume loss within one year after surgery is associated with postoperative delirium. MethodsLongitudinal structural MRI data and blood biomarkers were collected before surgery and one year postoperatively from 62 participants (>65 years, 27 females) undergoing major non-intracranial surgery. Hippocampal and other subcortical volumes were quantified using FreeSurfer. Cortical thickness was measured for cortical regions defined by the Desikan-Killiany (DK) atlas. One-year structural changes were examined in relation to peak Delirium Rating Scale (DRS) scores and one-year changes in plasma interleukin (IL)-6 levels. ResultsOne-year volume loss in the right hippocampus was significantly correlated with postoperative peak DRS scores and the one-year change in IL-6. Additional gray matter reductions were observed in the right putamen and the right superior parietal cortex. Right putamen volume loss was also associated with the one-year change in IL-6, while cortical thinning in the right superior parietal cortex was associated with peak DRS scores. ConclusionsPostoperative delirium is associated with longitudinal gray matter loss following surgery. Delayed resolution of inflammation may also contribute to postoperative brain structural changes. Clinical trial registrationNCT01980511 and NCT03124303.
Matching journals
The top 12 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Distinct clinical phenotypes and their neuroanatomic correlates in chronic traumatic brain injury 89%
- Accelerated decline in white matter microstructure in subsequently impaired older adults and its relationship with cognitive decline. 89%
- Hyperconnectivity and altered dynamic interactions of a nucleus accumbens network in post-stroke depression 89%
Similar papers in this journal
- Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings 88%
- AIM2 Inflammasome Mediates Hallmark Neuropathological Alterations and Cognitive Impairment in a Mouse Model of Vascular Dementia 88%
- Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors 87%
Similar papers in this journal
- Multimodal imaging suggests potential immune-vascular contributions to altered regional brain perfusion and oxygen metabolism in Post-COVID-19 Syndrome 89%
- Intermittent systemic exposure to lipopolysaccharide-induced inflammation disrupts hippocampal long-term potentiation and impairs cognition in aging male mice 89%
- Loss of tissue non-specific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis 89%
Similar papers in this journal
- Incidence and risk factors for post-stroke delirium in the elderly: a national inpatient sample (NIS) analysis 91%
- Effects of Weather and Season on Human Brain Volume 89%
- Associations between regional blood-brain barrier disruption, aging, and Alzheimers disease biomarkers in cognitively normal older adults 89%
Similar papers in this journal
- Overnight caloric restriction prior to cardiac arrest and resuscitation leads to improved survival and neurological outcome in a rodent model 89%
- Clinical Factors Associated with Microstructural Connectome Related Brain Dysmaturation in Term Neonates with Congenital Heart Disease 88%
- Longitudinal Resting-State fMRI of Awake Mice During Habituation: Stress, Head Motion, and Functional Connectivity 87%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.